| UpsesyLousy | Дата: Пятница, 03.05.2013, 06:44 | Сообщение # 1 |
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Группа: Гости
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| famuyiyaob | Дата: Вторник, 30.12.2014, 00:11 | Сообщение # 2 |
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Группа: Гости
| Tamoxifen is an enemy of the estrogen receptor in breast conglomeration via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a conflicting agonist/antagonist. Tamoxifen is the accustomed endocrine (anti-estrogen) therapy in place of hormone receptor-positive tit cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also many a time hardened in that setting.[1 -
Some titty cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also tie up to the estrogen receptor but do not activate it. Because of this competitive antagonism, tamoxifen acts like a pitch fragmented off in the stabilize b commit that prevents any other cue from being inserted, preventing estrogen from binding to its receptor. For that bosom cancer chamber spread is blocked.
Tamoxifen was discovered during pharmaceutical company Noble Chemical Industries[2 - (age AstraZeneca) and is sold subordinate to the traffic names Nolvadex, Istubal, and Valodex. However, the hypnotic, unvarying before its patent ending, was and motionless is extremely referred to through its generic standing "tamoxifen."
Medical uses
Heart of hearts cancer
Tamoxifen is currently occupied in return the treatment of both premature and advanced ER+ (estrogen receptor positive) soul cancer in pre- and post-menopausal women.[3 - Additionally, it is the most common hormone treatment instead of male mamma cancer.[4 - It is also approved by the FDA for the forestalling of breast cancer in women at drugged endanger of developing the disease.[5 - It has been moreover approved in the direction of the reduction of contralateral (in the opposite bust) cancer.
In 2006, the sturdy STAR clinical on concluded that raloxifene is equally powerful in reducing the occurrence of knocker cancer, but after an for the most part 4-year bolstering there were 36% fewer uterine cancers and 29% fewer blood clots in women winsome raloxifene than in women fascinating tamoxifen, although the discrepancy is not statistically significant.[6 - [7 - [8 -
In 2005, the ATAC trial showed that after average 68 months following a 5 year adjuvant treatment, the group that receivedanastrozole (Arimidex) had significantly more wisely results than the tamoxifen platoon in measures like disease free survival, but no comprehensive mortality benefit.[9 - Facts from the tribulation suggest that anastrozole should be the preferred medication to save postmenopausal women with localized breast cancer that is estrogen receptor (ER) positive.[10 - Another study develop that the risk of recurrence was reduced 40% (with some imperil of bone fracture) and that ER adversary patients also benefited from switching to anastrozole.[11 - [12 -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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